Products of Conceptus

PRODUCTS OF CONCEPTUS

PRODUCTS OF CONCEPTUS (POC) TESTING USING NGS

After abortion, fetal/placental issue can be analyzed for checking for common chromosomal abnormalities. As many as 70 % of first trimester pregnancy losses are due to genetic problems in the fetus especially autosomal trisomy, monosomy and triploidy. Traditionally, the testing for chromosomal disorders is done by karyotyping. For this one has to first successfully culture the cells of the POC. However, in many instances there may be failure to culture the fetal/placental cells or there may be maternal contamination of the cultured cells resulting in erroneous reporting BAUFICI GENETICS offers you NGS technology for analyzing POC. Next gen sequencing can help give POC results in 2 to 6 weeks, without the need of culturing the cells. The products can be sent in saline at ambient temperature.

The information obtained by analyzing the POC, is very important, from the point of managing the patient in the next pregnancy. In a patient of recurrent pregnancy loss, an abnormal PO in the previous pregnancy can help the clinician to focus on the genetic problem and offer the couple a wait and watch Tender loving care management or offer then IVF with PGTa. Same would be the case if there is a couple with balanced translocation, in whom the POC is carrying the defect.On the other hand a normal POC result, will enable the clinician to focus on non genetic, maternal related etiologies of recurrent miscarriages such as uterine abnormalities, hormonal disorders and autoimmune problems.